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Sabhya Rana, Ph.D.

Principal Investigator

Sabhya is an Assistant Professor in the Department of Neuroscience and the Belford Center for Spinal Cord Injury at Ohio State University. She received her B.S. in Biological Sciences from the University of California, Irvine and worked at the Reeve Irvine Research Center. She then completed her Ph.D. in Neuroscience at the Mayo Clinic in Rochester, Minnesota, under the mentorship of Dr. Carlos B. Mantilla and Dr. Gary C. Sieck. Her doctoral work focused on pre- and post-synaptic mechanisms of neuroplasticity in phrenic motor neurons. Sabhya trained in the lab of Dr. David Fuller (Breathing Research and Therapeutics Center (BREATHE)) at the University of Florida, where she investigated the impact of AMPA receptor allosteric modulators (Ampakines) to enhance motor function (respiratory and bladder) in pre-clinical models of spinal cord injury. 

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Sabhya’s current research program is dedicated to elucidating the pathophysiology of spinal injuries, with a particular focus on spinal motor control mechanisms. Given that respiratory failure is the leading cause of mortality following traumatic spinal cord injuries, she is motivated to develop innovative strategies to preserve and restore independent breathing. Funded by a K99/R00 mechanism through NINDS, Sabhya is currently exploring pharmacological and non-invasive neuromodulation approaches to achieve these objectives.

 

Sabhya is also deeply committed to supporting conversations between the spinal cord injury community and researchers in order to make meaningful strides toward a cure (read more: SHARPI-OSCIRS). 

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Education and training

2019-2024

University of Florida

Postdoctoral Fellow

Mentor:  Dr. David D. Fuller (about)

2014-2019

Mayo Clinic

PhD in Neuroscience

Mentors: Dr. Carlos B. Mantilla (about), Dr. Gary C. Sieck (about)

2008-2011

University of California, Irvine

Bachelor of Science

Biological Sciences, Excellence in Research

Funding

2024-2029

NIH

K99/R00 The NIH Pathway to Independence Award

National Institute of Neurological Disorders and Stroke (NINDS)

Title: Spinal Direct Current Stimulation to Enhance Breathing Following Cervical Spinal Cord Injury

(about)

2023-2024

Parker B Francis Foundation

Parker B Francis Foundation Fellowship (About)

Title: Trans-spinal Direct Current Stimulation and Ampakine Therapy to Enhance Breathing 

Role: Principal Investigator

$225k for 3 yrs 

*Relinquished in 2024 to accept K99

2021-2023

Craig H. Neilsen Foundation

Spinal Cord Injury Research on the Translational Spectrum: Craig H. Neilsen Foundation (About)

Title: Ampakine mediated respiratory recovery following cervical spinal cord injury

Role: Principal Investigator

$150,000 for 2 yrs

Center Affiliations

The Belford Center for Spinal Cord Injury (Belford)

Center for Brain Injury Recovery & Discovery (CBIRD)

Institute of Brain, Behavior and Immunology (IBBI)

Gene Therapy Institute (GTI)

Dorothy M. Davis Heart and Lung Research Institute (DHLRI)

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The Ohio State University Wexner Medical Center

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684 Biomedical Research Tower

460 W. 12th Ave, Columbus, OH 43210

614.814.6309 Office

sabhya.rana@osumc.edu

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